Currently, the prevalent approach is to contain the spread of the virus by reducing interpersonal contacts and vaccination. An alternative strategy could involve the understanding of the molecular mechanisms underlying the known risk factors and to correct them, when possible, as a prevention/treatment of the disease. The decrease of glutathione (GSH) is one of the biochemical alterations identified as being linked to the risk factors through several clinical research papers globally.

Glutathione has been used clinically through oral, topical and intravenous route for many years. Several randomized controlled trials and extensive medical literature on glutathione has shown the safety and efficacy of this molecule as an antioxidant, hepatoprotective and anti-inflammatory agent. When the world is struggling to combat a record surge in infections and fatalities with this second wave, Adroit Biomed repurposes the use of glutathione for prevention, management and recovery from COVID-19.

Addressing the need for role of Glutathione in the age of COVID-19

“Glutathione (GSH), known also as the master anti-oxidant, has been known for its effective immunity generating properties. However, one of its lesser-known properties, as an anti-inflammatory agent has not been in the focus until now. Research published in international journals are evaluating the possible Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 infection,” shares Dr Anish Desai Director Strategic Medical Affairs, Adroit Biomed.

Experts believe somewhere between 10 per cent and 30 per cent of COVID-19 patients develop long-term symptoms, including fatigue, chronic pain, brain fog, shortness of breath and gastrointestinal problems, though the severity of these can vary. Clinical studies reveal that increase in blood Glutathione levels elevate Natural Killer (NK) cell activity up to 400 times and increase Lymphocyte proliferation, Glutathione is also well studied for its anti-inflammatory activity and may prevent cytokine storm. A case report from Russia has documented association of low glutathione levels with higher severity of infections. Additionally, glutathione’s antioxidant, anti-inflammatory and muscle reparative activities helps to recover faster post-infection.